Main types of drug metabolized by cytochrome P450 isozymes

Main types of drug metabolized by cytochrome P450 isozymes

CypP450 1A2
Antidepressants – tricyclics, mirtazepine, fluoxetine*
Antipsychotics – clozapine, haloperidol, olanzapine, phenothiazines
Sedative/hypnotics – zopiclone
Beta-blockers – propranolol, warfarin, theophylline

CypP450 2C19
Antidepressants – amitriptyline, clomipramine, imipramine, moclobemide, citalopram
Antipsychotics – olanzapine
Mood stabilizers – phenytoin, valproate, topiramate
Sedative/anxiolytics – diazepam, barbiturates
Beta-blockers – propranolol

CypP450 2D6
Antidepressants – tricyclics, fluoxetine*, paroxetine*, sertraline*, mirtazepine, venlafaxine, mianserin
Antipsychotics – phenothiazines, haloperidol, clozapine, olanzapine, quetiapine
Antiarrhythmics – encainide, flecainide, mexiletine
Beta-blockers – alprenolol, metoprolol, propranolol, timolol
Opiates – codeine, dextromethorphan, ethylmorphine

CypP450 3A3/4
Antidepressants – tricyclics, nefazodone*, fluoxetine*, fluvoxamine*, citalopram, mirtazepine, venlafaxine
Antipsychotics – chlorpromazine, clozapine, pimozide, quetiapine, risperidone
Anxiolytics – clonazepam, diazepam, temazepam, triazolam, alprazolam, midazolam, buspirone
Anticonvulsants – ethosuximide, carbamazepine
Calcium channel blockers – diltiazem, felodipine, nifedipine, verapamil
Antibiotics – clarithromycin, erythromycin
Others – omeprazole, cisapride, dapsone, lavastatin