Adrenergic receptors
Ahlquist, in 1948, first proposed that noradrenaline could produce its diverse physiological effects by acting on different populations of adrenoceptors, which he termed a and b receptors. This classification was based upon the relative selectivity of adrenaline for the a receptors and isoprenaline for the b receptors; drugs such as phentolamine were found to be specific antagonists of the a, and propranolol for the b receptors.
Ahlquist, in 1948, first proposed that noradrenaline could produce its diverse physiological effects by acting on different populations of adrenoceptors, which he termed a and b receptors. This classification was based upon the relative selectivity of adrenaline for the a receptors and isoprenaline for the b receptors; drugs such as phentolamine were found to be specific antagonists of the a, and propranolol for the b receptors.
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